Risk of Seizures Following DTP and MMR Vaccines

Vaccines and Febrile Seizures: Quantifying the Risk.

Vaccines can cause fever, and fever in young children can lead to febrile seizures; these facts are not new. Febrile seizures are the most common seizure disorder of childhood and occur in ∼5% of all children, usually those younger than 24 months. We know that vaccines, often administered to children in this age group, can trigger febrile seizures. The article by Duffy et al1 in this edition of...

Evaluation of Adventitious Agents in MMR & Oral Poliomyelitis Vaccines

Background and Aims: Adventitious agents, especially viral agents are among the most important concerns in viral vaccines. Viral contamination of biological products may arise from the original source of the reagents such as, serum, trypsin, animal or human derived media components or cell culture and working seed or cross contamination of vaccine during production. In this study, adventitious ...

The Risk of Febrile Seizures Following Influenza and 13-Valent Pneumococcal Conjugate Vaccines

The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine.

BACKGROUND The administration of the diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccine and measles, mumps, and rubella (MMR) vaccine has been associated with adverse neurologic events, including seizures. We studied the relation between these vaccinations and the risk of a first seizure, subsequent seizures, and neurodevelopmental disability in children. METHODS This cohor...

Vaccines and febrile seizures.

Vaccine administration is the second leading cause of febrile seizures (FS). FS occurrence in children is a serious concern because it leads to public apprehension of vaccinations. This review discusses the clinical implications of FS, its potential link to vaccinations and its impact on official recommendations for vaccinations in children. Vaccines such as the pertussis antigen-containing vac...